Robert Weinberg from MIT writes in Newsweek (why?) about current state of cancer research:
"Mutations, while necessary, are not sufficient. Something else—something from outside the cancer cell—needs to fan the flames. A cell with several mutations may be primed to become cancerous, or may even be in the sluggish early stages of cancer, but that cell usually needs to be stimulated by additional growth-promoting signals to become a full-blown tumor. In fact, development of the great majority of human cancers is likely to be driven by these non-mutagenic "cancer promoting" molecular signals."
Yes, we've known the limitations of the gene mutation theory for eons, Bob. Thank you for finally admitting it. As for "additional growth-promoting signals," it sounds similar to the phrase "exogenous co-factors" which is science-babble for "we have no clue what's going on".
Go learn something about aneuploidy, Bob.